A Greedy Promoter Controls Malarial Var-iations
نویسنده
چکیده
Immune evasion by the malaria parasite Plasmodium falciparum is mediated by the mutually exclusive expression of a single member of the var family of genes, which encode variant surface antigens. In a recent paper in Nature, demonstrate that a construct carrying a transcriptionally active var promoter is sufficient to promote allelic exclusion of the parasite's endogenous var gene.
منابع مشابه
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متن کاملA silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron.
Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting promoter activation does not affect the transcription of chromosomal var genes.
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Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by the var gene family, undergoes antigenic variation and plays an important role in chronic infection and severe malaria. Only a single var gene is transcribed per parasite, and epigenetic control mechanisms are fundamental in this strategy of mutually exclusive transcription. We show that subtelomeric upsB var gene promote...
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متن کاملPlasmodium falciparum var gene silencing is determined by cis DNA elements that form stable and heritable interactions.
Antigenic variation in the human malaria parasite Plasmodium falciparum depends on the transcriptional regulation of the var gene family. In each individual parasite, mRNA is expressed exclusively from 1 var gene out of ∼60, while the rest of the genes are transcriptionally silenced. Both modifications to chromatin structure and DNA regulatory elements associated with each var gene have been im...
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ورودعنوان ژورنال:
- Cell
دوره 124 شماره
صفحات -
تاریخ انتشار 2006